Can a ketogenic diet prevent heart failure?

A gamey fatness, moo carb diet reversed affection bankruptcy in a sneak model of the discipline. A 24-hour fast besides led to improvements, mimicking the physiologic effects of the diet .Someone cooking fish in a frying pan share on Pinterest

Image credit: Sellwell/Getty Images. In people with affection failure, the muscle on the right or entrust side of the kernel — or on both sides — weakens. This stultification limits the electric organ ’ randomness ability to pump blood around the body, causing tire and shortness of breath, among early symptoms. The precede causes are high blood pressure, diabetes, and ischemic heart disease, in which the heart muscle becomes starved of oxygen. The National Heart, Lung, and Blood Institute estimate that about 5.7 million people in the United States have affection failure. There is presently no cure, but medications and life style changes can improve people ’ s quality of life and increase their life. healthy kernel muscle can draw upon a variety show of chemical energy sources, depending on the circumstances. One of these is a atom called pyruvate, which the body generates during the breakdown of the boodle glucose. However, conditions such as heart failure and diabetes reduce this flexibility, starving the muscle of the fuel it needs to function effectively.

Fuel shuttle

Researchers have nowadays traced this loss of tractability to a conveyer belt protein that shuttles pyruvate into mitochondria — the alleged office stations of cells. Known as the mitochondrial pyruvate carrier wave ( MPC ) building complex, it comprises two subunits : MPC1 and MPC2. Researchers at the Saint Louis University School of Medicine in St. Louis, MO, led a team who discovered that the production of both subunits is reduced in failing human hearts. The researchers compared heart tissue samples from people undergoing affection surgery with tissue samples from donor hearts that were goodly but unsuitable for transplant. They then showed that mice that lack the gene for producing MPC2 steadily develop heart failure over time. Their hearts became outsized, or hypertrophied, and the organs’ ability to pump blood diminished. crucially, the scientists found that they could reverse the price to the animals ’ heart muscle by plainly feeding them a special diet for 3 weeks. “ interestingly, this kernel bankruptcy can be prevented or even reversed by providing a high fatness, low carbohydrate ‘ ketogenic ’ diet, ” explains Kyle S. McCommis, Ph.D., adjunct professor of biochemistry and molecular biology at the university, who led the research. “ A 24-hour fast in mouse, which is besides ‘ ketogenic, ’ besides provided significant improvement in center recast, ” he adds.

Ketogenic diet

The ketogenic diet has been growing in popularity in late years, with research suggesting that it has a range of possible health benefits. These include supporting weight personnel casualty, improving center health, and preventing seizures in some types of epilepsy. By sternly restricting the intake of carbohydrates, such as glucose and other sugars and starches, the diet forces the body to break down adipose tissue, producing molecules called ketones that it can use as fuel. Intermittent fast may achieve like effects, though adhering to the regimen can be challenging. The new research indicates that a ketogenic diet promotes the breakdown of fatty acids in heart muscle cells. This process produces an alternative fuel called acetyl-CoA, which the mitochondria can use as an energy source instead of pyruvate. “ Thus, these studies suggest that pulmonary tuberculosis of higher fat and lower carbohydrate diets may be a nutritional therapeutic intervention to treat center failure, ” says McCommis. The scientists showed that the diet reversed kernel bankruptcy by promoting the breakdown of fatty acids in mitochondrion preferably than ketones. Supplying the mitochondrion with extra ketones only slightly improved heart bankruptcy.

Converging evidence

The findings from this learn appear in the daybook Nature Metabolism. Two studies by other research groups, which feature in the same issue, independently show that the MPC transporter protein plays a central role in heart failure. P. Christian Schulze and Jasmine M. F. Wu, who are both cardiologists from the University Hospital Jena in Germany, have written a comment article for the daybook about the three papers. While respective questions remain unanswered about the regulation of MPC levels in healthy and fail hearts, they conclude :

“ The stream findings suggest a character for particular ketogenic diets as a supportive, nonpharmacologic treatment in people with affection failure. ”

The cardiologists speculate that the findings could besides inspire the exploitation of new drugs for heart failure that influence by boosting the breakdown of fatso acids in heart muscle cells.

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Category : Healthy