Hass Avocado Composition and Potential Health Effects

respective clinical studies suggest that xanthophylls, exchangeable to those found in avocado, may have antioxidant and DNA protective effects with possible healthy aging protective effects. One cogitation was conducted involving 82 male airline pilots and patronize air out travelers who are exposed to high levels of cosmic ionize radiation known to damage DNA, potentially accelerating the aging process ( Yong et al., 2009 ). There was a significant and inverse association between consumption of vitamin C, beta-carotene, β-cryptoxanthin, and lutein-zeaxanthin from fruits and vegetables and the frequency of chromosome translocation, a biomarker of accumulative DNA damage ( p < 0.05 ). In another trial, lipid peroxidation ( 8-epiprostaglandin F2a ) was correlated inversely with plasma xanthophyll levels ( Haegele et al., 2000 ). In other studies, inverse correlations were found between xanthophyll and oxidative DNA wrong as measured by the comet assay, and in contrast to beta-carotene ( Hughes et al., 2009 ; Thomson et al., 2007 ). NHANES psychoanalysis suggests that xanthophylls intake decreases with aging ( Johnson et al., 2010 ). A cross-sectional cogitation examined the kinship between skin anti-aging and diet choices in 716 japanese women ( Nagata et al., 2010 ). After controlling for covariates including long time, smoking status, BMI, and life sun exposure, the results showed that higher intakes of entire dietary fatten were importantly associated with more peel elasticity. A higher intake of green and yellow vegetables was importantly associated with fewer wrinkles ( Nagata et al., 2010 ). several preclinical studies suggest that avocado components may protect skin health by enhancing injure bring around activity and reducing UV price ( Nayak et al., 2008 ; Rosenblat et al., 2011 ) .


Avocados contain a phone number of bioactive phytochemicals including carotenoids, terpenoids, D-mannoheptulose, persenone A and B, phenols, and glutathione that have been reported to have anti-carcinogenic properties ( Ding et al., 2009 ; Jones et al., 1992 ; Ames, 1983 ). The concentrations of some of these phytochemicals in the avocado may be potentially efficacious ( Jones et al., 1992 ). presently, direct avocado anti-cancer activity is identical preliminary with all data based on in vitro studies on homo cancer cell lines. cancer of the larynx, throat, and oral cavity are the elementary area of avocado cancer investigation. Glutathione, a tripeptide composed of three amino acids ( glutamic acerb, cysteine, and glycine ) functions as an antioxidant ( Flagg et al., 1994 ). The National Cancer Institute found that avocado ‘s glutathione levels of 8.4 mg per 30 guanine or 19 mg per one-half fruit is respective fold higher than that of other fruits ( Flagg et al., 1994 ). flush though the body digests glutathione gloomy to individual amino acids when foods are consumed, a boastfully population-based subject controlled study showed a meaning correlation coefficient between increased glutathione intakes and decreased risk of oral and guttural cancer ( Castillo-Juarez et al., 2009 ). One clinical learn found that plasma xanthophyll and total xanthophylls but not individual carotenes or entire carotenes reduced biomarkers of oxidative try ( urinary concentrations of both total F2-isoprostanes and 8-epi-prostaglandin ) in patients with early-stage ( in situ, stage I, or stage II ) cancer of larynx, throat, or oral pit ( Hughes et al., 2009 ). Xanthophyll rich avocado extracts have been shown in preclinical studies to have anti-Helicobacter pylorus activity for a likely consequence on gastritis ulcers, which may be associated with gastric cancer risk ( Castillo-Juarez et al., 2009 ).

dietary carotenoids show likely summit cancer protective biological activities, including antioxidant action, initiation of apoptosis, and inhibition of mammary cell proliferation ( Thomson et al., 2007 ). Studies examining the role of fruits and vegetables and carotenoid consumption in relative to breast cancer recurrence are limited and report mix results ( Thomson et al., 2007 ). In preclinical studies, total carotenoids and xanthophyll appear to reduce oxidative stress, a potential trigger for breast cancer ( Ding et al., 2007 ). In women previously treated for breast cancer, a significant inverse association was found between total plasma carotenoid concentrations and oxidative try ( Thomson et al., 2007 ), but more clinical research is needed to confirm this line up. Mammographic concentration is one of the strongest predictors of breast cancer risk ( Tamimi et al., 2009 ). The association between carotenoids and breast cancer risk as a function of mammographic density was conducted in a cuddle, case-control discipline consisting of 604 breast cancer cases and 626 controls with prospectively measured circulating carotenoid levels and mammographic concentration in the Nurses ’ Health Study ( Tamimi et al., 2009 ). overall, circulating total carotenoids were inversely associated with breast cancer risk ( p = 0.01 ). Among women in the highest tertile of mammographic concentration, raised levels α-carotene, β-cryptoxanthin, lycopene, and lutein/zeaxanthin in the blood were associated with a 40–50 % reduction in breast cancer risk ( phosphorus < 0.05 ). In contrast, there was no inverse association between carotenoids and breast cancer hazard among women with low-mammographic concentration. These results suggest that plasma levels of carotenoids may play a function in reducing front cancer risk, particularly among women with high mammographic concentration. There are no direct avocado breast cancer clinical studies. exploratory studies in prostate gland cancer cell lines suggest antiproliferative and anticancer effects of avocado lipid extracts ( Lu et al., 2005 ). Lutein is one of the active components identified. There are presently no human studies to confirm this electric potential xanthophyll and prostate cancer relationship .

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